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Home » Joe Rogan Podcast #2454: w/ Robert Malone (Transcript)

Joe Rogan Podcast #2454: w/ Robert Malone (Transcript)

Editor’s Notes: In this episode of the Joe Rogan Experience #2454, Dr. Robert Malone returns nearly five years after his landmark first appearance to reflect on the evolution of COVID-19 discourse and the validation of early concerns regarding mRNA technology. The conversation delves into Malone’s personal experiences with vaccine adverse events, the mechanics of lipid nanoparticles, and the psychological concept of “mass formation” used to describe societal behavior during global crises. Moving beyond the pandemic, Rogan and Malone explore the future of biotechnology and the ethical implications of emerging tools like artificial wombs. This episode offers a provocative deep dive into the intersection of medicine, public policy, and the shifting landscape of scientific information. (Feb 13, 2026) 

TRANSCRIPT:

The Return After Five Years

JOE ROGAN: Yep. We’re up. Okay. We were trying to figure out how long it’s been since you came here. It’s been somewhere in the neighborhood, close to five years.

DR. ROBERT MALONE: Yeah. A lot of water under the bridge.

JOE ROGAN: Your appearance on this show. Boy, did that create a lot of problems.

DR. ROBERT MALONE: Yeah, Yeah, I didn’t expect ever having me on again. I thought maybe Spotify was just going to say, hell, no.

JOE ROGAN: No, you were right. Like, this is a victory dance. Like, it turned out that all your warnings and all the things that you were saying about the problems turned out to be true.

DR. ROBERT MALONE: Well, thanks. I know you’ve said that on a few shows. Every time you do, somebody sends me a clip and sees, hey, Rogan said you did the right thing.

JOE ROGAN: What was it like for you? First of all, you know, they were trying to label you a quack and a kook, and you didn’t know what they were talking about. I don’t think it worked with everybody. I mean, it worked with people that weren’t paying attention, but anybody that really paid attention to your background said, no, this guy’s very credible. I mean, don’t you have, like, nine patents on mRNA vaccine technology?

DR. ROBERT MALONE: Yeah, on the mRNA? Yeah. And total of about 15, I think.

JOE ROGAN: Yeah. And you also took the vaccine and had a horrible adverse event, a series of them.

DR. ROBERT MALONE: Yeah.

JOE ROGAN: Yeah.

DR. ROBERT MALONE: That, at the time, it was so early. That was when the National Guard was still doing it, and that was Moderna. And I was embarrassed to have these experiences, and I was embarrassed when I got Covid in early 2020.

You know, looking back, there was so much fear, so much anger and anxiety and everything wrapped around all of this. And in retrospect, it was, you know, it was promoted, but it was also very organic. You know, it was, you know, looking back, being honest about it, it was a frightening time, what was happening.

And yeah, I, you know, I had those experiences. My doc, who was a cardiologist, was like, why were you so stupid to take this?

JOE ROGAN: Your doctor said that, too. In 2021.

DR. ROBERT MALONE: Yeah, she was 2020 or 20. What? It was 2021. 2021. Yeah. I was going to a kind of a cardiologist that had left traditional medical practice at UVA and the associated hospitals, and I was going to her for hormone replacement therapy and bioidentical hormone replacement therapy, and she was monitoring a lot of things.

And, yeah, that was her response. Why did you do this? Of course I’ve had that question a thousand times since. You know, why were you so stupid? You were the one that should have known. And so I have to answer that still. It kind of gets a little tiresome.

Early Concerns About mRNA Technology

JOE ROGAN: What was your perspective on the vaccine before you took it?

DR. ROBERT MALONE: To be honest, I was a little, I was amazed. I was amazed that the claims that the problems that I encountered when I had been working on it had been solved. I didn’t see how that could be the case, but I knew that a huge amount of money had been thrown at it. So it was possible.

JOE ROGAN: What were the problems?

DR. ROBERT MALONE: In my hands, it was inflammation, primarily. It was also, you know, the, it was absolutely not localizable. It was in the monkey models that we tested, it was incredibly inflammatory. It didn’t give long levels, long, prolonged levels of expression. It was hard to make.

It’s kind of, back then, it was almost a little bit of witchcraft you’d drop. I mean, for me as a graduate student, when I was doing that, it was incredibly scary because it was a couple thousand dollars worth of reagents in a little tiny tube. And, you know, back in the late 80s, that was real money. And it didn’t always work, the reaction. So, you know, it was a little bit of a wing and a prayer.

But then as I started working with animal models and with the different formulations, I could come up with a variety of different compounds and formulations that worked pretty well in cell culture, but not so well in animals. And I spent a lot of time trying to do that, optimize that.

And what I ended up with is just seeing that it, it really caused, you know, I’m sorry to use medical jargon, I’m, that’s kind of where I’m from. So that’s the language.

JOE ROGAN: No, it’s probably better.

DR. ROBERT MALONE: It caused a lot of inflammation, you know, white cell infiltrates, really aggressive white cell infiltrates in my hands in both mice and monkeys. And I’d abandoned it as something that just, you know, was useful in research, in particularly in cell culture. But I just didn’t see it maturing as a, as an efficient delivery strategy with low risk, you know, acceptable risk in animals.

And that also became the experience in at this company that I had first joined, where a lot of the original patents were filed.