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Home » Diary Of A CEO: w/ Glucose Goddess Jessie Inchauspé (Transcript)

Diary Of A CEO: w/ Glucose Goddess Jessie Inchauspé (Transcript)

Editor’s Notes: With your diet during pregnancy, you’re literally programming your baby’s DNA—and most expecting moms are never told how powerful that is. In this conversation, biochemist and “Glucose Goddess” Jessie Inchauspé reveals how sugar, protein, and key nutrients like choline and omega‑3s can shape your child’s lifelong risk of diabetes, obesity, and even ADHD. She breaks down the four biggest mistakes in modern pregnancy diets, the simple daily food swaps that can cut glucose spikes dramatically, and why eating “for two” is one of the biggest lies moms are sold. If you’re pregnant, planning to be, or love someone who is, this episode is your practical blueprint for giving a baby the best start possible—without spending a fortune or counting every calorie. (Feb 26, 2026)

TRANSCRIPT:

The Glucose Goddess on Blood Sugar, Mood, and Modern Food

STEVEN BARTLETT: Jessie Inchauspé, the Glucose Goddess. For people that don’t know who you are, what have you spent the best part of the last decade committing your life to and why?

JESSIE INCHAUSPÉ: My work started in the glucose space, meaning the blood sugar space. I was showing people how blood sugar impacts all of us on a daily basis. The spikes and dips after we eat, they lead to inflammation, faster aging, cravings, fatigue. And it’s been the basis of my work because glucose matters for everybody and it is the core of a healthy body and mind. And so that’s where I started because it’s so important.

What Two Years of New Research Revealed

STEVEN BARTLETT: We last spoke almost two years ago now. What have you learned in those last two years that has evolved your own thinking or has developed your own thinking in any way? If we reflect on the last conversations we had around glucose spikes and sugar and the health consequences and diets, is there anything you’ve learned in those two years that is interesting and new?

JESSIE INCHAUSPÉ: Oh, absolutely. I think mostly the impact of glucose on mood and on relationships. For example, there’s this fascinating study that took married couples and they gave the husband and the wives a little voodoo doll representing their spouse. And the researchers told the participants to put a little pin in the voodoo doll every time their spouse annoyed them.

At the end of the two weeks, the researchers counted the number of pins in the voodoo dolls, and they also measured the participants’ glucose levels. They found that the people who had the most glucose lows had put the most pins in the voodoo doll representing their spouse.

STEVEN BARTLETT: Wow.

JESSIE INCHAUSPÉ: So it’s just an association, but it’s interesting. And scientists then found that when you have very unsteady glucose levels, it impacts this neurotransmitter in your brain called tyrosine that manages your mood. So it seems that with unsteady glucose levels, your mood is less stable, which could then correlate to you being more annoyed at your spouse. So I think studies like this have really blown my mind.

What Happens During a Glucose Crash

STEVEN BARTLETT: What’s going on when we go through a glucose crash, per se?

JESSIE INCHAUSPÉ: Glucose is your body’s energy, so your brain is constantly monitoring how much glucose we have in our bloodstream. And steady glucose is great. When your glucose levels crash, this indicates biologically that you’re out of fuel. And this is a powerful signal to your body and your brain to say, “Alert, alert. We need food. We need more glucose.”

And so it creates all these downstream consequences on your mood. You become hangry. All you think about is food. You’re in a bad mood. You’re like, “I need to eat something.” You look for a banana, you look for a cookie. It can also activate the craving center in your brain that says, “Steven, go find some chocolate.” And science has shown this — low glucose levels create a cascade of consequences on how we feel and what we seek.

Now, what’s interesting is that back in the day when we had low glucose levels — I’m talking like hunter-gatherer times — they wouldn’t arrive so quickly because we didn’t have these big spikes that then led to these big, drastic drops. It was more balanced. We ate with less sugar, obviously. So when our glucose became low, it was a bit more gradual.

Today, because we have access to all this sugar, we can spike our glucose very quickly. And as a result, it then crashes very quickly. So the effects are pretty much immediate and they’re very intense. All of a sudden, you go from feeling okay to your brain being in alert mode. “We need to find more fuel.” So we’ve dysregulated our glucose levels to the point where it’s impacting us in a very unnatural way.

How Modern Fruit Has Been Engineered

STEVEN BARTLETT: Is that in part because we modify our food? Even fruit? When I looked back through the history of fruit, apples, bananas, et cetera, looked extremely different before they were modified to be juicier and sweeter, et cetera.

JESSIE INCHAUSPÉ: Completely. It’s like dogs. So all the dog breeds today, from Chihuahuas to golden retrievers, they all come from wolves. Humans have been breeding wolves together to create these different species of dogs. They all have that ancestor of the gray wolf. So humans are very good at breeding natural things to serve their purposes. And when it comes to fruit, it’s the same thing.

As you say, if you compare an ancestral banana or an ancestral apple to a modern one, completely different. And you should pull up these photos — they’re fascinating. Ancestral banana: tiny, full of fiber, full of seeds, not very sweet. And then modern banana: full of sugar, low in fiber, really easy to eat. So that’s the first thing people need to know about fruit. Fruit is not natural. Fruit is the product of human engineering.

However, a piece of whole fruit also contains fiber and water. So even though it’s been bred to have a lot of sugar, the fiber and the water reduce how quickly the sugar arrives in our bloodstream, making it more or less okay for us.

But the problem comes when we denature that piece of fruit — meaning if we remove the fiber.