Home » A 50-cent microscope that folds like origami by Manu Prakash (Transcript)

A 50-cent microscope that folds like origami by Manu Prakash (Transcript)

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Manu Prakash

Manu Prakash, an assistant professor of bioengineering at Stanford University, talks at TED conference…

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The year is 1800. A curious little invention is being talked about. It’s called a microscope. What it allows you to do is see tiny little life forms that are invisible to the naked eye. Soon comes the medical discovery that many of these life forms are actually causes of terrible human diseases. Imagine what happened to the society when they realized that an English mom in her teacup actually was drinking a monster soup, not very far from here. This is from London.

Fast forward 200 years. We still have this monster soup around, and it’s taken hold in the developing countries around the tropical belt. Just for malaria itself, there are a million deaths a year, and more than a billion people that need to be tested because they are at risk for different species of malarial infections.

Now it’s actually very simple to put a face to many of these monsters. You take a stain, like acridine orange or a fluorescent stain or Giemsa, and a microscope, and you look at them. They all have faces. Why is that so, that Alex in Kenya, Fatima in Bangladesh, Navjot in Mumbai, and Julie and Mary in Uganda still wait months to be able to diagnose why they are sick? And that’s primarily because scalability of the diagnostics is completely out of reach. And remember that number: one billion.

The problem lies with the microscope itself. Even though the pinnacle of modern science, research microscopes are not designed for field testing. Neither were they first designed for diagnostics at all. They are heavy, bulky, really hard to maintain, and cost a lot of money. This picture is Mahatma Gandhi in the ’40s using the exact same setup that we actually use today for diagnosing TB in his ashram in Sevagram in India.

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Two of my students, Jim and James, traveled around India and Thailand, starting to think about this problem a lot. We saw all kinds of donated equipment. We saw fungus growing on microscope lenses. And we saw people who had a functional microscope but just didn’t know how to even turn it on. What grew out of that work and that trip was actually the idea of what we call Foldscopes.

So what is a Foldscope? A Foldscope is a completely functional microscope, a platform for fluorescence, bright-field, polarization, projection, all kinds of advanced microscopy built purely by folding paper.

So, now you think, how is that possible? I’m going to show you some examples here, and we will run through some of them. It starts with a single sheet of paper. What you see here is all the possible components to build a functional bright-field and fluorescence microscope.

So, there are three stages: There is the optical stage, the illumination stage and the mask-holding stage. And there are micro optics at the bottom that’s actually embedded in the paper itself. What you do is, you take it on, and just like you are playing like a toy, which it is, I tab it off, and I break it off.

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