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Home » Derek Munro of More Plates More Dates on Joe Rogan Podcast #2421 (Transcript)

Derek Munro of More Plates More Dates on Joe Rogan Podcast #2421 (Transcript)

Here is the full transcript of Derek Munro of More Plates More Dates on The Joe Rogan Experience #2421, December 2, 2025.

Joe welcomes back Derek from More Plates, More Dates for a long-form deep dive into nootropics, performance supplements, and what actually works versus hype. They break down Derek’s new Gorilla Mind energy drink “Red Gummy Fish,” including its ingredients, dosing strategy, and how he used years of self-experimentation and research to design it. From caffeine and creatine to wild old-school pre-workouts, steroid-era bodybuilding, TRT, and Hollywood transformations, this episode is packed with unfiltered talk about chasing peak performance without destroying your health.

The Joe Rogan Experience #2421: Derek Munro on Nootropics and Performance Enhancement

JOE ROGAN: Tell me about your new drink. Look at this. To your red gummy fish. I’m about to try it for the first time and this is a nootropic.

DEREK MUNRO: Yeah. So I think on the first episode maybe that I did with you.

JOE ROGAN: Ooh, robust.

DEREK MUNRO: Eh?

JOE ROGAN: That’s good. Yeah, that’s delicious. You mean robust. You’re saying it like a potentially.

DEREK MUNRO: Oh, both flavor and I think it’s great. Oh, right on.

JOE ROGAN: Red gummy fish. It’s fing delicious. I drink the s out of this. Oh, a lot of stuff in here. What’s in here?

Breaking Down the Gorilla Mind Formula

DEREK MUNRO: So I think it was the first time I was on, you asked me about Gorilla Mind and the nootropic formula that I used before podcasts and how to get cognitively dialed. And at the time it was a capsule based formula and still is, it still exists.

But taking what we could to suspend in a liquid format and getting it into something that’s more publicly and widely accepted that they would want to drink on a regular basis and it’s something you could use daily. It’s kind of what we did in this.

So we included essentially a daily use version of the Gorilla Mind formula, which includes the tyrosine precursor for dopamine as well as other neurotransmitters, catecholamines like adrenaline, noradrenaline, also alpha GPC. Most bioavailable form of choline. It crosses the blood brain barrier and is pretty efficacious and also just a good choline source in general, which most people are deficient in as a nutrient and I think completely unaware that it’s actually important to be supplementing with. Potentially pretty hard to get an adequate amount of choline.

JOE ROGAN: But where does it come from in food?

DEREK MUNRO: Liver is a good source. Eggs and in general it’s just the highly nutrition dense foods that you would get it from. A lot of people aren’t focusing on specifically either because of caloric density or it’s an animal based nose to tail thing or fill in the blank.

It’s not impossible to do it. A lot of people who focus on it could probably relatively easily, but it’s still one of the things you have to focus on actually kind of maneuvering into your diet typically. So in general, most people are at least maybe 50% of the way that are at best. And that’s even among people who I would say are relatively balanced diet individuals.

So I’m sure you’re familiar with cholinergics and their cognition and whatnot. Caffeine. Tried and true.

JOE ROGAN: How much you got in here?

DEREK MUNRO: 200 milligrams.

JOE ROGAN: Nice.

DEREK MUNRO: Very difficult decision trying to come up with what is the amount you’re going to stick with in perpetuity in this thing.

JOE ROGAN: Everyone’s addicted now. It’s a real issue with caffeine.

The Caffeine Balance and Unique Ingredients

DEREK MUNRO: So it’s the fine balance of not too much, something that is still tolerable, sustainable, going to be widely accepted and widely impactful on a beneficial level, but not overdoing it. And 200 is kind of what we landed on.

And then uridine monophosphate, pretty unique ingredient. I haven’t seen anybody ever included a drink, let alone even in supplements typically.

JOE ROGAN: What is it?

DEREK MUNRO: So it’s also something that operates via the cholinergic system, but in a different way. Mainly its utility is kind of enhancing your sensitivity to stimulants. So somebody who is otherwise desensitized from heightened exposure to things that either desensitize them to caffeine or nicotine or things of this nature, even something like the ADHD medications.

This can actually, at least the literature suggests strongly, that it enhances dopamine neurotransmission potential. So almost restoring function and damaged dopamine producing neurons in the brain. So you can kind of get a heightened impact out of the same level of stimulant.

So a caffeine dose that might otherwise be, you’re used to it now, you start to feel it again more than you used to without having to increase your caffeine intake. Yeah, so it’s a pretty cool ingredient and it seems to have some neuroprotective properties potentially as well and some interesting literature on Alzheimer’s and whatnot. But it’s more fringe and to be determined how impactful it is.

And then on top of that we have L-Theanine. You’re probably familiar with its effect. Stacked with caffeine increases alpha waves, good for verbal fluency as well as just general attention, concentration, but keeping you a little bit more balanced and mellow while you have the heightened stimulatory activity from the caffeine and the other kind of dopaminergic compounds.

And then also saffron extract, which is a totally unique inclusion in my opinion. Still don’t really see the nootropic formula, let alone in drinks. And it’s something that in literature is shown to be as efficacious as pharmaceutical SSRIs without inducing the same erectile dysfunction inducing effects of it, and without causing the same anhedonia inducing effects, which is kind of the muting of pleasure in the brain.

So Saffron, yeah, super interesting ingredient. It seems to be pretty impactful for depression, for anti-anxiety.