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Home » Huberman Lab: w/ David Choe on the Power of Creative Transmutation (Transcript)

Huberman Lab: w/ David Choe on the Power of Creative Transmutation (Transcript)

Here is the full transcript of artist David Choe’s interview on Huberman Lab Podcast with host Andrew Huberman, December 22, 2025.  

Brief Notes: In this extraordinary and raw episode of the Huberman Lab, Andrew Huberman sits down with legendary artist David Choe for a three-hour masterclass on transmuting deep trauma and addiction into profound creative expression. Choe shares his unfiltered life story, from the “shame-chasing” loops of severe gambling and workaholism to his time in a Japanese prison and his pivotal role in the early days of Facebook.

The duo explores the neurobiology of addiction as a “spiritual problem” and the vital importance of radical honesty in the journey from the head to the heart. Whether discussing his friendship with Anthony Bourdain or his decision to finally “sit with himself,” Choe offers a powerful roadmap for anyone looking to reclaim their agency and thrive.

Welcome and Introduction

ANDREW HUBERMAN: Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life. I’m Andrew Huberman and I’m a professor of neurobiology and ophthalmology at Stanford School of Medicine.

My guest today is David Choe. David Choe is an artist. He’s a highly accomplished painter, graffiti and street artist, writer, podcaster, and television host. Many of you are perhaps familiar with David as the guy who famously painted the original Facebook offices, took equity for the job, and got rich.

Now, that’s a wild story, but David’s whole life journey, what he did prior to and after that, and what he has overcome along the way, is a million times wilder. As he shares today, David grew up hearing and thinking that he was destined for greatness, but also hearing and thinking that he was a total disgrace.

Today, he talks with complete openness and vulnerability about addiction, about cycles of success and failure, and about channeling and overcoming deep shame. Today’s podcast is unlike any other that I’ve hosted. David is wide open about his childhood abuse, his massive success, then career setbacks, relapses, and transmuting every possible emotion into art along the way.

So no matter who you are, David’s story, and just as importantly, how he’s living right now, how he shows up on this podcast will change what you think is possible for you in life. It will force you to look inward and to use whatever joy and pain you have inside of you to be the best human being you can possibly be.

David Choe is, as we say in science, an n of 1, meaning there is no other like him. Yes, because of his incredible art, but also for his willingness to share so openly and honestly so that others can benefit and grow. I consider it a true honor and privilege to host David on this podcast. And frankly, it’s impossible not to love him.

This one is incredibly raw and honest. It’s also full of surprises, many of which are fun surprises, so buckle up. Before we begin, I’d like to emphasize that this podcast is separate from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public.

In keeping with that theme, today’s episode does include sponsors. And now for my discussion with David Choe. David Choe, welcome.

DAVID CHOE: Thank you for having me, man.

ANDREW HUBERMAN: Huge, longtime fan.

ANDREW HUBERMAN: Love your art.

ANDREW HUBERMAN: I’ve been super inspired by your YouTube channel. I watch it sometimes before I do my drawing or I prepare for a podcast.

DAVID CHOE: What are you drawing?

On Art and Anatomy

ANDREW HUBERMAN: I draw a lot of anatomy on top of some paintings. So I do neuroanatomy on top of some paintings that my friend Tim Armstrong’s been doing. Musician at Leeds Inner Ranch.

DAVID CHOE: Is it anatomically correct or is it, like, exaggerated or is it?

ANDREW HUBERMAN: This is a really good question. So in essence, it’s anatomically correct. But around the turn of the last century, two guys, Cajal and Golgi, won the Nobel Prize for drawing the nervous system and showing these things no one had seen before. And they stripped away everything except—

DAVID CHOE: I’m going to come paint with you.

ANDREW HUBERMAN: Yeah.

DAVID CHOE: I don’t like what’s happening in your painting studio.

ANDREW HUBERMAN: Okay.

DAVID CHOE: Just from what you said so far, it’s not good.

ANDREW HUBERMAN: Okay.

DAVID CHOE: But it’s good because you did that. And then now we have to strip that away. We have to get at the core of it, because painting is—wait, weren’t you in the middle of complimenting me? Like, keep going.

ANDREW HUBERMAN: I mean, I love your YouTube channel. I watch it before I prepare podcasts and before I paint or draw. And I live—I converted an art gallery into the living space, and somehow I thought that that would make me more inspired, but it turns out it does. A lot of things do. But I think the key with anatomy and trying to teach science with drawings is can’t be too much detail, can’t be too little detail. Otherwise people are overwhelmed.

The Journey from Head to Heart

DAVID CHOE: It’s the best thing for I think everyone. But for someone like you, who spends a lot of time in your head, I always say the longest journey you’ll ever take in your life is from your head to your heart. And to be an intellectual person, you just live a lot. You try to rationalize and apply logic to everything.

So painting is not that. Music is not that. Creating is not that. It’s just to get to this. And so for—but it sounds just in the little that you’ve explained, that your painting is very methodical, which is super meticulous.

ANDREW HUBERMAN: I want to include every cell type. Yeah.

DAVID CHOE: What’s your threshold for positive affirmations? Can I go now, like you?

ANDREW HUBERMAN: I mean, I like to think I have a thick skin, but—all right, let’s go.

DAVID CHOE: No, it’s all love.