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Home » Sam Altman: How to Win When AI Changes Everything (Transcript)

Sam Altman: How to Win When AI Changes Everything (Transcript)

Read the full transcript of OpenAI CEO Sam Altman in conversation with Zerodha’s co-founder Nikhil Kamath on People by WTF podcast on “How to Win When AI Changes Everything”, August 14, 2025.

OpenAI CEO Sam Altman on How to Win When AI Changes Everything

NIKHIL KAMATH: Hi, Sam.

SAM ALTMAN: Hey, Nikhil, how are you?

NIKHIL KAMATH: I’m good.

SAM ALTMAN: Sorry I’m late. I got caught up in getting ready for the launch tomorrow and lost track of time and excitement with the final results.

NIKHIL KAMATH: But no worries. I’m guessing it must be really hectic, right?

SAM ALTMAN: It is a very hectic day.

GPT-5: A Quantum Leap in AI Capability

NIKHIL KAMATH: I have the model and I’ve been playing with it a little bit. How is it different? Sam, I’m not an expert at this.

SAM ALTMAN: So, yeah, there’s all these ways we can talk about, you know, it’s better at this metric or it can do this amazing coding demo that GPT-4 couldn’t. But the thing that has been most striking for me is in ways that are both big and small, going back from GPT-5 to our previous generation model is just so painful. It’s just worse at everything.

And I’ve taken for granted that there is a fluency and a depth of intelligence with GPT-5 that we haven’t had in any previous model. It’s an integrated model, so you don’t have to pick in our model switcher and know if you should use GPT-4o or o3 or o4 mini or any of the complicated things. It’s just one thing that works and it is like having PhD level experts in every field available to you 24/7 for whatever you need, not only to ask anything, but also to do anything for you.

So if you need a piece of software created, it can kind of do it from scratch all at once. If you need a research report on some complicated topic, it can do that for you. If you needed to plan an event for you, it could do that too.

NIKHIL KAMATH: Is it more agentic in nature in the sense that sequential tasking, you’re one step closer to it? Because I was trying that.

SAM ALTMAN: It’s much better at things like that. The robustness and reliability has greatly increased and that’s very helpful for agentic workflows. So I’m very impressed by how long and complex of a task it can carry out.

Career Advice for the AI Generation

NIKHIL KAMATH: So we did a call a couple of weeks ago when I was bugging you about what sectors and themes to invest in for the next decade. So I don’t want to talk about that too much. I thought we’ll keep today about first principles and how the world is changing. By virtue of all that is changing in the world that you dominate.

So the very first thing I want to start with is if I were a 25-year-old boy or girl living in Mumbai or Bangalore in India. I know you’ve said a bunch of times that colleges are not holding on to the place of relevance they might have had when I was growing up, but what do I do now? What do I study? If I’m starting a company, what kind of company do I start? Or if I were to even find a job, what industry do you think has some kind of tailwind? I’m not talking 10 years down the line, but even as close as three to five years down the line.

SAM ALTMAN: First of all, I think this is probably the most exciting time to be starting out one’s career maybe ever. I think that 25-year-old in Mumbai can probably do more than any previous 25-year-old in history could. It’s really amazing what you can do with a tool like this.

I felt the same way when I was 25 and the tools then were not as amazing as tools we have now, but we had the computer revolution and we could do things. A 25-year-old then could do things that no 25-year-old in history before would have been able to and now that’s happening in a huge way.

So whether you want to start a company or be a programmer or go work in any other industry, you know, create new media, whatever it is. The ability for one person to use these tools and have great ideas and implement them with what would have taken decades of experience or teams of people is really quite remarkable.

In terms of particular industries, I am very excited about what AI is going to mean for science and the amount of science that one person will be able to discover and the rate at which they can do that. Clearly it’s transforming what it means to program computers in a huge way and people will be able to create completely new kinds of software and at huge new scale.

Definitely for startups, you know, if you have an idea for a new business, the ability for a very tiny team to do a huge amount of work is great. But it feels like this is just now a very open canvas. People are limited to a degree that they’ve never been before only by the quality and creativity of their ideas. And you have these incredible tools to help you realize them.

GPT-5 and India’s Growing Market

NIKHIL KAMATH: Is there anything in particular you want to say about GPT-5? Then I can ask you questions around that.

SAM ALTMAN: GPT-5 does feel to us like it’s going to be another big step forward in how people use these systems. The level of capability, the level of robustness, the reliability and the ability to use this just for a lot of tasks in life to create software, to answer questions, to learn to work more efficiently. This is a pretty significant step forward.

Each time we’ve had one of these, we have been amazed by the human potential it unlocks.