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Home » Diary Of A CEO: w/ Stanford Neuroscientist Dr. David Eagleman on Brain Plasticity (Transcript)

Diary Of A CEO: w/ Stanford Neuroscientist Dr. David Eagleman on Brain Plasticity (Transcript)

Editor’s Notes: In this episode of The Diary Of A CEO, Stanford neuroscientist Dr. David Eagleman reveals the true biological purpose of dreaming: a critical defense mechanism used to protect the brain’s visual territory from being overtaken by other senses during the night. Dr. Eagleman explores the fascinating world of brain plasticity, explaining how we can “sculpt” our own brains to become more motivated and disciplined by seeking challenges that fall in the zone between frustration and achievement. The discussion also covers the importance of “cognitive reserve” and why staying socially and mentally active as we age is the best way to prevent cognitive decline. (April 23, 2026)

TRANSCRIPT:

The Moment That Sparked a Lifelong Fascination

STEVEN BARTLETT: David Eagleman, what made you so fascinated about the brain, and why should everybody listening be fascinated about the brain as well?

DR. DAVID EAGLEMAN: Here’s what I think it is. When I was 8 years old, I fell off of the roof of a house that was under construction, and I fell 12 feet and broke my nose on the floor below. But the whole thing seemed to take a long time. I did the calculation and figured out that it only took 0.6 of a second to get from the top to the bottom, and I couldn’t figure out why it seemed to have taken so long.

So I think that got me really interested in perception and the machinery by which we view the world and take it in, and what is actually real versus what’s a construction of the brain. And that’s what I’ve devoted my career to, is figuring out how the brain, which is locked inside the skull — it’s about 3 pounds — how it constructs this model of the world, and which things we can take as reality, which things we shouldn’t.

You Are Not One Person — You Are a Team of Rivals

STEVEN BARTLETT: I think most people don’t even know they have a — that there’s a brain there, almost. It sounds like a strange thing to say, but we’ve never really — most of us haven’t really seen our own brains at all. We’ve never been able to, we don’t touch our own brains at all. So it’s easy to fall into the trap of thinking that everything I experience is true and is reality. So I’m wondering how a deeper understanding of all this stuff can help me live a better life.

DR. DAVID EAGLEMAN: Yeah, one of the things that I started writing about years ago is that I think we’re not — I think we often think of ourselves as individuals, meaning not divisible into other things, but really, you are a team of rivals. You’ve got all these neural networks that have different drives making different suggestions to you.

STEVEN BARTLETT: What’s a neural network?

DR. DAVID EAGLEMAN: So in the brain, you’ve got 86 billion cells called neurons, and these are communicating with each other at a blindingly fast rate. Many of these cells are hooked up in networks. So they’re, you know, this guy’s talking to this guy and this guy, and they’re all in particular networks.

The thing is, you can actually get competing networks. So for example, Steven, if I drop some chocolate chip cookies in front of you, part of your brain wants to eat it. It’s a good energy source. Part of your brain says, don’t eat it, I’ll gain weight. Part of you says, okay, I’ll eat one, but I’ll go to the gym tonight. The point is, you are arguing with yourself. You are conflicted.

This is what makes humans so interesting, is that we have all these voices trying to drive us to different conclusions about our behavior. So the way that your ship of state moves depends on the vote of the neural parliament at any time. So understanding this, I think, is really critical to navigating our own lives, because all of us do things where retrospectively we regret it. We say, oh, I shouldn’t have eaten that whole bag of chips or done the alcohol or the drugs or whatever. Everybody has regrets all the time with things, and it’s because you have different voices in charge at different times.

The Ulysses Contract: Protecting Your Future Self

DR. DAVID EAGLEMAN: Part of what this leads to is what we call the Ulysses Contract. So a Ulysses Contract is where you do something now to prevent yourself from behaving badly in the near future. Just as an example, when people go to Alcoholics Anonymous, the first thing they’re told is clear all the alcohol out of the house. Because even if you feel like, look, I’m in a moment of sober reflection, I don’t want to ever drink again — if you have alcohol in the house, you’re going to bust into that cabinet at some point on a festive Saturday night or a lonely Sunday night or whatever.

So what you do is you constrain your future behavior by setting things up in the right way so your future — the future you — can’t behave badly. We naively think, okay, well, I know who I am, I’m just one person. But you’re not. And under different circumstances, you’re tempted by different things and you’ll do different kinds of behavior. So having a sense of what’s going on under the hood gives us an opportunity to be more closely aligned with the kind of person we would like to be.

STEVEN BARTLETT: Because it feels like there’s just one. Well, I do argue with myself in my head sometimes, but it feels like there is just one me. And so when I hear that voice say, Steve, you should have that cookie and it’s 1 a.m., and then the other voice says, no, you shouldn’t — I think it’s kind of the same person just tussling with himself.

DR. DAVID EAGLEMAN: Right. Well, but that tussling with himself implies different political parties that are all battling it out.