The Brain May Be Able To Repair Itself — With Help: Jocelyne Bloch (Transcript)

Following is the full text of neurosurgeon Jocelyne Bloch’s talk titled “The Brain May Be Able To Repair Itself — With Help” at TED conference.

Jocelyne Bloch – Neurosurgeon

So I’m a neurosurgeon. And like most of my colleagues, I have to deal every day with human tragedies. I realize how your life can change from one second to the other after a major stroke or after a car accident.

And what is very frustrating for us neurosurgeons is to realize that unlike other organs of the body, the brain has very little ability for self-repair.

And after a major injury of your central nervous system, the patients often remain with a severe handicap. And that’s probably the reason why I’ve chosen to be a functional neurosurgeon.

WHAT IS A FUNCTIONAL NEUROSURGEON?

It’s a doctor who is trying to improve a neurological function through different surgical strategies. You’ve certainly heard of one of the famous ones called deep brain stimulation, where you implant an electrode in the depths of the brain in order to modulate a circuit of neurons to improve a neurological function.

It’s really an amazing technology in that it has improved the destiny of patients with Parkinson’s disease, with severe tremor, with severe pain.

However, neuromodulation does not mean neuro-repair. And the dream of functional neurosurgeons is to repair the brain. I think that we are approaching this dream.

And I would like to show you that we are very close to this. And that with a little bit of help, the brain is able to help itself.

So the story started 15 years ago. At that time, I was a chief resident working days and nights in the emergency room. I often had to take care of patients with head trauma.

You have to imagine that when a patient comes in with a severe head trauma, his brain is swelling and he’s increasing his intracranial pressure. And in order to save his life, you have to decrease this intracranial pressure.

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And to do that, you sometimes have to remove a piece of swollen brain. So instead of throwing away these pieces of swollen brain, we decided with Jean-François Brunet, who is a colleague of mine, a biologist, to study them.

What do I mean by that? We wanted to grow cells from these pieces of tissue. It’s not an easy task. Growing cells from a piece of tissue is a bit the same as growing very small children out from their family.

So you need to find the right nutrients, the warmth, the humidity and all the nice environments to make them thrive. So that’s exactly what we had to do with these cells.

And after many attempts, Jean-François did it. And that’s what he saw under his microscope. And that was, for us, a major surprise.

Why? Because this looks exactly the same as a stem cell culture, with large green cells surrounding small, immature cells. And you may remember from biology class that stem cells are immature cells, able to turn into any type of cell of the body.

The adult brain has stem cells, but they’re very rare and they’re located in deep and small niches in the depths of the brain. So it was surprising to get this kind of stem cell culture from the superficial part of swollen brain we had in the operating theater.

And there was another intriguing observation: Regular stem cells are very active cells — cells that divide, divide, divide very quickly. And they never die, they’re immortal cells.

But these cells behave differently. They divide slowly, and after a few weeks of culture, they even died. So we were in front of a strange new cell population that looked like stem cells but behaved differently.

And it took us a long time to understand where they came from. They come from these cells. These blue and red cells are called doublecortin-positive cells. All of you have them in your brain. They represent 4% of your cortical brain cells. They have a very important role during the development stage.

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When you were fetuses, they helped your brain to fold itself. But why do they stay in your head? This, we don’t know.

We think that they may participate in brain repair because we find them in higher concentration close to brain lesions. But it’s not so sure.

But there is one clear thing — that from these cells, we got our stem cell culture. And we were in front of a potential new source of cells to repair the brain. And we had to prove this.

So to prove it, we decided to design an experimental paradigm. The idea was to biopsy a piece of brain in a non-eloquent area of the brain, and then to culture the cells exactly the way Jean-François did it in his lab.

And then label them, to put color in them in order to be able to track them in the brain.

And the last step was to re-implant them in the same individual. We call these autologous grafts — autografts.

So the first question we had, “What will happen if we re-implant these cells in a normal brain, and what will happen if we re-implant the same cells in a lesioned brain?”

Thanks to the help of professor Eric Rouiller, we worked with monkeys. So in the first-case scenario, we re-implanted the cells in the normal brain and what we saw is that they completely disappeared after a few weeks, as if they were taken from the brain, they go back home, the space is already busy, they are not needed there, so they disappear.

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