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Mel Robbins Podcast: w/ Dr. Nadine Burke Harris on Nervous System Reset (Transcript)

Editor’s Notes: In this powerful episode of The Mel Robbins Podcast, world-renowned trauma expert and pediatrician Dr. Nadine Burke Harris joins Mel to discuss how childhood stress can physically rewire the adult brain. Together, they explore the concept of “Adverse Childhood Experiences” (ACEs) and how they manifest in adulthood as chronic health issues, anxiety, and reactive behaviors. Dr. Burke Harris introduces the transformative practice of “buffering”—a science-backed method to calm an overactive stress response and reclaim control over your biology. Whether you are looking to heal from your own past or better understand the people in your life, this conversation offers a hopeful, research-driven playbook for neurological and emotional recovery. (April 27, 2026) 

TRANSCRIPT:

Introduction: Breaking Free from the Patterns of Your Past

MEL ROBBINS: Dr. Burke Harris is here to teach you how to break free from the patterns in your past so you can finally heal yourself and feel in control of your emotions, your thoughts, your actions, and your life. Dr. Nadine Burke Harris is one of the most important voices in trauma science and public health. She is a medical doctor, a pediatrician who trained at Stanford University, and she holds a master’s in public health from Harvard.

MEL ROBBINS: Dr. Nadine Burke Harris, welcome to the Mel Robbins Podcast.

DR. NADINE BURKE HARRIS: Thank you so much for having me.

MEL ROBBINS: I am a tremendous admirer of your work, and I would love for you to start by explaining how might my life be different if I take everything to heart that you’re about to share with us about this extraordinary research related to experiences in your childhood and how they manifest in your behavior as an adult and what you can do to set yourself free. What could change about my life if I really apply what I’m about to learn from you?

DR. NADINE BURKE HARRIS: The biggest thing that will change in your life if you apply this is that stress is no longer going to be in the driver’s seat of your life.

MEL ROBBINS: Okay.

DR. NADINE BURKE HARRIS: Understanding how stress gets under our skin and changes our biology allows us to use that biology and work with it instead of working against it. And so, it’ll help us understand ourselves better, and also to be able to understand the people in our lives better.

And so, I think if folks really apply this science to their lives, what they’ll find, number one, is that it can improve their health and well-being. Number two, relationships will become less reactive and more connected. And number three, it’s a guidepost around how to set up your life for the support that we need to be functioning in a way that’s just more balanced and less effortful going forward.

What Trauma Really Is — And Why It’s Not What You Think

MEL ROBBINS: That would be nice to be able to move through your day without feeling like you’re dragging the weight of the world or that you’re in a straitjacket that you seem to have put yourself in. And I believe you because your work has had a huge impact on me.

In fact, understanding both in myself when there were patterns that I didn’t quite understand or things that would trigger me, or I would get easily emotionally flooded and pissed off and screaming at people, and then I’m apologizing, and then I didn’t understand why, and I just felt like I couldn’t change my behavior. I thought there was something wrong with me because I felt like somehow I was choosing to be this way.

And a lot of what your work has done for me is to help me see that there are a lot of things about my behavior, at least that used to be present, that were part of the biological and the neurological conditioning that happened during my childhood, and that this is true for everybody.

And so what I’d love to dig into, because I do think everything that you’re going to teach us today is profoundly life-changing, like you’ll never look at yourself, your childhood, or anybody around you the same again. Let’s talk a little bit about what is trauma, and your work specifically talks about adverse childhood experiences. What is trauma?

DR. NADINE BURKE HARRIS: At its core, trauma is the biological response to overwhelming stress.

MEL ROBBINS: Okay.

DR. NADINE BURKE HARRIS: So a lot of us think of it as the stressor, the thing that happened to us.

MEL ROBBINS: Yeah.

DR. NADINE BURKE HARRIS: But it’s actually the body’s reaction to that stress.

MEL ROBBINS: Oh, I think I had this wrong for a long time. I always thought trauma was the thing that happened. You’re saying trauma is your body’s response to the thing that happened? That’s right. And not only in the moment that it happened, but that it continues to respond in similar ways.

DR. NADINE BURKE HARRIS: Exactly right.

MEL ROBBINS: After it. Okay, I get it now.

The Patient Who Stopped Growing: A Turning Point

MEL ROBBINS: You know, one of the things that’s really amazing about your work is you are the first researcher to connect childhood trauma and chronic stress to all kinds of things like heart disease, autoimmune disorder, diabetes, cancer, substance abuse, and things that are even more subtle that we struggle with in our adult lives that we may not realize are tied to something deeper. What was it that made you lean in, in terms of what you were seeing in your patients to start to put these pieces together, Dr. Burke Harris?

DR. NADINE BURKE HARRIS: Well, to be honest, what really happened for me was I started my career, my clinical practice, opening a clinic in one of San Francisco’s most underserved neighborhoods because I was really motivated by improving health outcomes for the vulnerable. And what I was seeing was that over and over again, patients were being referred to me for ADHD, or attention deficit hyperactivity disorder.

As I was doing what I was trained to do — history and physical — for a lot of my patients, it felt like there was a disconnect.