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Home » Transcript: The Future of U.S. AI Leadership with Dario Amodei of Anthropic

Transcript: The Future of U.S. AI Leadership with Dario Amodei of Anthropic

Read the full transcript of CEO Speaker Series where Michael Froman interviews Anthropic CEO and Cofounder Dario Amodei. This conversation discusses the future of U.S. AI leadership, the role of innovation in an era of strategic competition, and the outlook for frontier model development. [Mar 11, 2025]

Listen to the audio version here:

TRANSCRIPT:

Introduction

MICHAEL FROMAN: Well, good evening, everybody. Welcome. My name is Mike Froman, I’m president of the council, and it’s a great pleasure to have you here tonight for one of our CFR CEO speaker series and to have the CEO and co-founder of Anthropic, Dario Amodei, with us tonight.

Dario was vice president of research at OpenAI, where he helped develop GPT-2 and 3. And before joining OpenAI, he worked at Google Brain as a senior research scientist. I’m going to talk with Dario for about 30 minutes, then we’ll open it up to questions from people here in the hall. We have about 150 people here, we have about 350 online, and so we’ll try and get some of their questions in as well.

DARIO AMODEI: Thank you for having me.

Anthropic’s Origins and Mission

MICHAEL FROMAN: So you left OpenAI to start Anthropic, a mission-first public benefit corporation. Why leave? What are Anthropic’s core values? And how do they manifest themselves in your work? And let me just say, a cynic would say, well, this mission-first, this is all marketing. How can you give us some specific examples of how your product and strategy reflect your mission?

DARIO AMODEI: If I were to back up and kind of set the context, we left at the end of 2020. I think in 2019 and 2020, something was happening, which I think myself and a group within OpenAI, which eventually became my co-founders at Anthropic, were among the first to recognize. They’re called scaling laws or the scaling hypothesis today.

The basic hypothesis is simple. It says that—and it’s really a remarkable thing, and I can’t overemphasize how unlikely it seemed at the time—if you take more computation and more data to train AI systems with relatively simple algorithms, they get better at all kinds of cognitive tasks across the board. And we were measuring these trends back when models cost $1,000 or $10,000 to train.

So that’s a kind of an academic grant budget level. And we forecast that these trends would continue even when models cost $100 million, a billion, $10 billion to train, which now we’re getting to. And indeed, that if the quality of the models and their level of intelligence continued, they would have huge implications for the economy.

It was even the first time we realized that they would likely have very serious national security implications. We generally felt that the leadership at OpenAI was on board with this general scaling hypothesis, although many people inside and outside were not. But the second realization we had was that if the technology was going to have this level of significance, we really needed to do a good job of building it.

We really needed to get it right. In particular, on one hand, these models are very unpredictable. They’re inherently statistical systems.

One thing I often say is we grow them more than we build them. They’re like a child’s brain developing. So controlling them, making them reliable is very difficult.

The process of training them is not straightforward. So just from a system safety perspective, making these things predictable and safe is very important. And then, of course, there’s the use of them, the use of them by people, the use of them by nation states, the effect that they have when companies deploy them.

And so we really felt like we needed to build this technology in absolutely the right way. OpenAI, a bit as you’ve alluded to, was founded with some claims about that they would do exactly this. But for a number of reasons, which I won’t get into in detail, we didn’t feel that the leadership there was taking these things seriously.

And so we decided to go off and do this on our own. And the last four years have actually been a kind of almost a side-by-side experiment of what happens when you try and do things one way and what happens when you try and do things the other way and how it has played out.

Anthropic’s Commitment to Safety and Responsibility

So I’ll give a few examples of how we’ve really, I think, displayed a commitment to these ideas.

One is we invested very early in the science of what is called mechanistic interpretability, which is looking inside the AI models and trying to understand exactly why they do what they do. One of our seven co-founders, Chris Ola, is the founder of the field of mechanistic interpretability. This had no commercial value or at least no commercial value for the first four years that we worked on it.

It’s just starting to be a little bit in the distance, but nevertheless, we had a team working on this the whole time in the presence of fierce commercial competition because we believe that understanding what is going on inside these models is a public good that benefits everyone, and we published all of our work on it so others could benefit from it as well.

I think another example is we came up with this idea of constitutional AI, which is training AI systems to follow a set of principles, instead of training them from data or from mass data or human feedback. This allows you to get up in front of Congress and say these are the principles according to which we trained our model.

When we first came to when we had our first product, our first version of Claude, which is our model, we actually delayed the release of that model roughly six months because this was such a new technology that we just weren’t sure of the safety properties.