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Home » Dr. Daniel Amen on The Tucker Carlson Show (Transcript)

Dr. Daniel Amen on The Tucker Carlson Show (Transcript)

Here is the full transcript of American psychiatrist Dr. Daniel Amen’s interview on The Tucker Carlson Show titled “Big Pharma’s Most Dangerous Lie and the Dark Truth About Weed”, November 17, 2025.

The Physical Effects of Cannabis on the Brain

TUCKER CARLSON: Thank you, Doctor. You study the brain, not just emotions, but the physical brain, the actual biology of the brain. I’ve got a lot of questions for you about that, but let’s just start with cannabis. What are the effects of cannabis on the brain? Marijuana on the brain.

DR. DANIEL AMEN: So I published a study on a thousand marijuana users, compared it to our healthy group. Every area of their brain was lower in blood flow and activity. And then just this year, measurably. Measurably. On the imaging study we do, which is called SPECT, Single Photon Emission Computed Tomography. It looks at blood flow activity, but also looks at mitochondrial function.

TUCKER CARLSON: I have to ask you, so pardon my ignorance, what’s mitochondrial function?

DR. DANIEL AMEN: So the mitochondria, little energy powerhouses in your cell, they activate and keep the cell energized and alive. And 49% of the tracer that we do this study with is actually taken up by the mitochondria in the brain. So when we see low activity, that’s really low activity, along with decreased blood flow.

And then there’s a new study by a completely separate group than ours on 1,000 young marijuana users. And the areas of the brain involved in learning and memory were low in blood flow and activity. So it’s not just me because I have a problem with marijuana, it’s other scientists as well, saying marijuana is not great for the brain.

TUCKER CARLSON: What are the effects of less mitochondrial activity and lower blood flow?

DR. DANIEL AMEN: So it can go with tiredness, it can go with low motivation, it can go with depression. Over time, it can go with more anxiety because your brain can’t settle it down. And in vulnerable people, it can go with an increased risk of psychosis.

The Connection Between Marijuana and Psychosis

TUCKER CARLSON: How does that work? We’re all of a sudden seeing, because marijuana is not a drug, it’s a medicine. We’ve been told it’s the most healing medicine ever discovered. It’s, quote, “natural,” God made it, and it’s the answer to most of our physical and psychological problems.

And now all of a sudden, there seem to be all these studies showing a direct connection between heavy marijuana use and psychosis. Is that connection real? And if so, how exactly does that happen? Do we know?

DR. DANIEL AMEN: Well, it’s absolutely real. And people who have a certain genetic makeup are more vulnerable to becoming psychotic. One gene in particular, if you have a combination of an abnormality in that gene, you have a seven-fold, so that’s a 700% increased risk of becoming psychotic if you are a heavy user of marijuana.

So not for everybody, but for everybody, the risk is somewhere between two to four times, especially if you start young. And now it’s the young that are suffering from the idea that marijuana is innocuous because it’s not innocuous, but because they think it’s innocuous. I think psilocybin is going to go the same way.

When the perception of the dangerousness of a drug goes down, its use goes up. And that’s what we’ve seen. And teenagers who use have a higher incidence of anxiety, depression, suicide and psychosis in their 20s. And so you’re taking a developing brain and altering how that brain develops.

And what we’re seeing is the highest incidence of brain and mental health problems in young people we have ever seen. Study from the CDC: 57% of teenage girls report being persistently sad. 32% have thought of killing themselves. Think of that, of all teenage girls, 32% have thought of killing themselves.

TUCKER CARLSON: 32% of all teenage girls in the United States?

DR. DANIEL AMEN: Yes. 24% have planned to kill themselves and 13% have tried. We’re in this mental mess and we have to go, why?

Societal Lies About Drugs and Brain Health

DR. DANIEL AMEN: And it’s more complicated than just marijuana, but marijuana is clearly part of it, and part of it are the societal lies that I’ve seen from the 80s. So I started my psychiatric residency in 1982 and I trained at the Walter Reed Army Medical Center in Washington D.C.

And 1987, video games started to come out. And they’re like, oh, these are so exciting. With no neuroscience study on what do video games do to development. And it’s not good. There’s not been great studies that say, oh yeah, these are really great for brain development.

And then in the early 90s, alcohol is health food. Right. My first clinic is in Northern California. I have 11 clinics. And it was right outside the Napa Valley. And the Napa Valley produces a lot of wine in the United States. Was so excited. You should have a glass or two every night. And that’s good for your heart. No, it’s bad for your brain.

TUCKER CARLSON: And now a glass or two of wine is bad for your brain?

DR. DANIEL AMEN: The American Cancer Society came out four years ago against any alcohol, because any alcohol is associated with an increased risk of eight different cancers. And then we did a prize fight between marijuana and alcohol, and it went 12 rounds. Alcohol causes a lot of devastation, perhaps more than marijuana.

But the idea in society is alcohol is a health food. It’s a lie. And then “pain is the fifth vital sign.” You need opiates if you’re in pain. Well, that sort of didn’t turn out well. Or benzos or “mommy’s little helper.” And that didn’t turn out well.

TUCKER CARLSON: So these are all trends just in the 43 years since you’ve been practicing psychiatry.