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Sam Altman on RSI, AI Consciousness, OpenAI’s New Hardware (Transcript) 

In this wide-ranging interview, OpenAI CEO Sam Altman sits down with Matthew Berman to discuss recursive self-improvement (RSI), whether today’s AI models are conscious, and why OpenAI is building new consumer hardware. Altman also talks about AI-driven math and scientific discoveries, the Dot personal assistant, the future of compute, model personality, and why he believes AI should spark a new Renaissance rather than a new Industrial Revolution. Read the full transcript of this conversation which was premiered on October 21, 2026 below:

AI and the Era of Scientific Discovery

MATTHEW BERMAN: (00:00:49 – 00:00:51) All right, Sam, thank you so much for joining me.

SAM ALTMAN: (00:00:51 – 00:00:52) Yeah, thank you.

MATTHEW BERMAN: (00:00:52 – 00:01:05) So the first thing I want to talk about are some of the announcements that you made last week about all of the math proofs and the discoveries. And I think it seems incredible, but maybe you can contextualize it for a broader audience who may not be in the weeds.

SAM ALTMAN: (00:01:06 – 00:01:58) I think we are entering the era where AI is going to help us discover significant new knowledge. And we’ve been talking about this for a long time, and I maybe started earlier this year, but now it’s really, okay, the AI is doing very difficult things, figuring out very complicated, important new knowledge. And I believe that the same thing that has worked here for math is going to work for biology, help us get new medicines, materials science, help us get new sources of energy and much more.

So this is one of the things I’ve always been most excited about. I think this is going to do an enormous amount to really have an impact on people’s lives. It won’t feel directly like using AI, you’ll just be like, “Okay, the world got better and it’s just society doing its thing.” But I think the power of this will be transformative.

MATTHEW BERMAN: (00:01:59 – 00:02:12) And I think about having that kind of direct impact on society day to day. Is there anything that you think will stem from some of these discoveries in particular that people will feel? And what is the timeline for something like that?

SAM ALTMAN: (00:02:13 – 00:02:31) I would hope, well, the FDA process is going to take a while. So let me kind of give a timeframe to when I think we have a discovery of curing or treating a major disease or a candidate for that that has to go through testing. I would hope we have the candidate for that in the next couple of years for the first really major thing.

MATTHEW BERMAN: (00:02:31 – 00:02:40) Probably need to overhaul some of the post-discovery process to start to get cures and to market more quickly.

SAM ALTMAN: (00:02:40 – 00:03:01) I’m sure we need to overhaul it somewhat. I’m glad we have a process. I have no doubt that there’s room for improvement as there is in anything, and maybe there’s more than average here. But I am grateful that when we take a medicine, it is generally considered safe and has been tested. And I think that part’s good.

MATTHEW BERMAN: (00:03:02 – 00:03:10) Is there a particular project that was kicked off by AI, discovered by AI, that you’re really excited about that you think is kind of coming over the horizon soon?

SAM ALTMAN: (00:03:11 – 00:03:30) Personally, I think I’m most emotionally excited for a major physics discovery, and I’m hopeful that can come soon. I don’t know if that’s necessarily the most important thing for humanity as a whole, but it’s the one where I’m like, “Oh, I think we’re going to get it and it’s going to be so cool.”

How AI Is Changing Math and Coding

MATTHEW BERMAN: (00:03:31 – 00:03:45) There was some in the math community whose reaction was, “We didn’t ask for this.” And it felt very similar to how engineers, I think, first reacted to AI starting to write a lot of the code. Where do you think comes from? And how do you think that it’s going to transition?

SAM ALTMAN: (00:03:47 – 00:06:19) Coding was a very interesting one before we kind of go to where it comes from. The thing about coding is that people went through this, there’s no more jobs as coders for people, to coders are never going to be busier than they’ve been, and coders are never going to have more of an impact and make more money. Now, the texture of the job changed a lot. But the fact that we’re going to employ people to get computers to do things, that seems like it’s going to keep going for much longer than people thought. And people were so certain 6 or 12 months ago this was not the case. It’s like, “There’s no need.”

And I think there’s many lessons to learn from this, but one of the interesting ones is that the world actually had demand for just way more software than any of us thought at the time. And part of why I think some of the mathematicians are having the reaction they’re having is it’s not clear that the same thing applies to math.

However, where I think there is an analogy to coding is already you’re starting to see a similar shift happen that happened with coding, which is, “Okay, fine, maybe we’re not going to discover new math theorems or prove them in an unaided way anymore. Maybe that part is done or mostly done or ending.” But given that our whole society is focused on people doing useful things for each other, these kind of incomprehensible math proofs turned out to be not that helpful to people. And there’s now a lot of excitement about people who are going to take these new ideas, figure out what’s going on, and figure out a way to translate it to something that people can understand and write a beautiful proof for it.

I’m sure there will be other things too.