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Home » Transcript: Pharmacologist Andrew Gallimore on Joe Rogan Podcast #2403

Transcript: Pharmacologist Andrew Gallimore on Joe Rogan Podcast #2403

Read the full transcript of chemical pharmacologist and neurobiologist Andrew Gallimore’s interview on Joe Rogan Experience #2403, on DMT and the Nature of Reality, October 30, 2025.

INTRODUCTION

JOE ROGAN: How are you?

ANDREW GALLIMORE: Splendid. How the devil are you, sir?

JOE ROGAN: I think it’s the first time anyone’s answered splendid when I ask him, how you doing? So tell me about your book, man. Let me see the cover of it. First of all, death by astonishment, which is the famous Terence McKenna quote, right?

ANDREW GALLIMORE: Yes.

JOE ROGAN: All you have to fear is death by astonishment.

ANDREW GALLIMORE: Exactly. Yeah.

JOE ROGAN: You know, the first time I did DMT, I literally heard his words, “do not give in to astonishment.” I literally heard those words. It’s almost like whatever’s over there wanted me to hear that so I could sink in or whatever because I had already heard it before. So they wanted to say it to me as well. It was very weird.

ANDREW GALLIMORE: Yeah. It’s sage advice, I think.

JOE ROGAN: Oh, it’s the only way. Because if you freak out, well, it’s like, that’s a good thing. It’s good advice in most of life. Like, don’t give in to the freak out.

ANDREW GALLIMORE: Yeah, yeah.

The Book and the Beginning

JOE ROGAN: “Confronting the mystery of the world’s strangest drug.” How did you get involved in this?

ANDREW GALLIMORE: DMT?

JOE ROGAN: Yes.

ANDREW GALLIMORE: Oh, so you have to go back to my teenage years, really. I mean, I first heard about DMT through Terence McKenna, a friend—

JOE ROGAN: Like most of us.

ANDREW GALLIMORE: Yeah, like most of us. But this was during the dawn of the Internet, right.

JOE ROGAN: Long before you were a scientist.

ANDREW GALLIMORE: Long before I was a scientist, right. So a friend gave me this magazine. It had this interview with this bearded, cheeky looking fellow on the back called Terence McKenna. And he spoke about this thing called DMT, which of course I didn’t know what that was. But the stories that he was telling—that you were going to meet these insectoid aliens and trans-dimensional machine owls jabbering in an indecipherable tongue and singing impossible objects into existence—I mean, it sounded ridiculous, but I was hooked.

I thought, this is it. This is the most f*ing incredible thing I’ve ever read in my life. I was like 15, 16 years old and there was one computer in the school that was hooked up to the World Wide Web. So all of—

JOE ROGAN: What year was this?

ANDREW GALLIMORE: ’96. Oh, giving my age away here, but early days.

JOE ROGAN: Early days, yeah, yeah.

ANDREW GALLIMORE: So I spent all my time just going on to Alta Vista. You remember Alta Vista?

JOE ROGAN: I do, yeah. I didn’t remember it until you brought it up.

ANDREW GALLIMORE: There we go. Yeah. Just trying to find out as much as I could about this. And that was what triggered my decision to study chemistry and pharmacology. My academic journey was triggered by “I want to know.” It’s such a cool thing, the idea that you can put a molecule in your brain and it doesn’t just change how you feel, but it completely changes the entire structure of your reality.

Your entire world is obliterated and replaced with one that is completely alien. There’s no relationship whatsoever to the normal waking world. That’s incredible. And I wanted to try at least to understand how that actually works.

The Great Mystery

JOE ROGAN: Well, the weirdest part about that molecule is that your brain makes it. And so then you have to go, why? And what’s the purpose of that? And what are we really? What is consciousness and what is normal consciousness? What’s the purpose of it? And why does this chemical exist? Why does this molecule exist that’s produced by the brain that changes everything and seems to transport you to a place that’s more real than this physical reality that we find ourselves in right now?

ANDREW GALLIMORE: Exactly. And that is the great mystery. And I think most people who’ve learned about DMT, even scientists—I mean, I speak to scientists, I engage with neuroscientists often and they will say, “Oh, this is just hallucination, this is just your brain making it up.”

And I don’t think most scientists realize how confounding and how difficult to explain the DMT state is. I think it is one of life’s true mysteries. It is not simple to explain the DMT state.

JOE ROGAN: I think it’s almost irresponsible to try to explain it without experiencing it. It’s not going to kill you. It lasts 15 minutes. Stop being a pussy, just do it. And then tell me it’s just hallucination. That’s it, just do a big one. Three giant hits, come back. Tell me this is normal. Tell me this is just a freak out. Because it sure doesn’t seem like it, does it?

ANDREW GALLIMORE: No. And I mean, I first learned about DMT when I was 15 or 16, but my first experience was probably close to a decade later. And I thought before I took it, I kind of knew what to expect. I mean, I’d listened to all the Terence McKenna lectures I could find, I’d read all the books, read all the trip reports and I thought, “Okay, I’m ready for this. I kind of know what’s going to happen.”

And I wasn’t ready. And I was shocked. I was horrified. In a sense, I was appalled. I mean, this was impossible. This was an impossible experience. I was confronted with what seemed to me to be the undeniable hand of some kind of intelligence. And not just any kind of intelligence, but a supremely advanced, ancient, and yet highly technological intelligence.

And that was undeniable to me.