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Home » American Thought Leaders: with Neurosurgeon Dr. Michael Egnor (Transcript)

American Thought Leaders: with Neurosurgeon Dr. Michael Egnor (Transcript)

Here is the full transcript of renowned neurosurgeon Dr. Michael Egnor’s interview on American Thought Leaders with host Jan Jekielek, premiered December 11, 2025.

BRIEF NOTES: In this thought-provoking episode of American Thought Leaders, host Jan Jekielek sits down with renowned neurosurgeon Dr. Michael Egnor to discuss the scientific and philosophical evidence for the human soul. Dr. Egnor shares remarkable clinical stories of patients functioning normally despite missing large portions of their brains and examines why reason and free will cannot be elicited through direct brain stimulation.

From the “veridical” details of the Pam Reynolds near-death experience to the logical pitfalls of viewing humans as “meat machines,” this conversation bridges the gap between modern neuroscience and ancient wisdom. It is a compelling exploration of why the existence of an immortal soul is not just a matter of faith, but a conclusion supported by the most rigorous observations of the human mind.

Introduction

JAN JEKIELEK: This is American Thought Leaders, and I’m Jan Jekielek. Michael Egnor, such a pleasure to have you on American Thought Leaders.

DR. MICHAEL EGNOR: It’s a pleasure to be here. Thank you.

JAN JEKIELEK: So many of us believe, even those of us who are religious, that our consciousness sits in the brain and it’s a product of these perhaps electrical impulses, neurological connections that are happening in the brain. But you contend that something else is going on. Briefly explain to me that argument. We’re going to dig into it, of course, a lot further in a moment.

The Legacy of Wilder Penfield

DR. MICHAEL EGNOR: We’re not the first people to ask this question, to delve into this. There was a neurosurgeon and a neuroscientist named Wilder Penfield back in the early 20th century. He was really the greatest neuroscientist in the neurosurgical profession. And he began his career as a materialist. He believed that everything came from the brain.

But he asked this question earlier in his career: Does the brain explain the mind completely? And he sought the answer to that question through 40 years of clinical experience and research. And at the end of his career, he wrote a book called Mystery of the Mind. And he said, the answer to that question is no. The brain does not explain the mind completely.

There’s an aspect of the mind that is not from the brain. And I’ve had a similar experience. It was kind of a eureka moment when I was thinking that. And I read his book and I realized that he had had the same insight that I was having. So no, the brain does not explain the mind completely. It explains some parts of the mind, but not all parts of the mind.

JAN JEKIELEK: I think it’s even difficult to think about brain and mind separately. I mean, for me right now, and I’m inclined to believe what you’re saying is true, but just to fathom it is a little bit difficult.

The Cartesian Problem

DR. MICHAEL EGNOR: One of the reasons that we have that problem is René Descartes. Descartes was a philosopher back in the 17th century who changed the way we look at living things and at reality in general. And he believed that living things were machines of sorts. They were meat machines, biological machines, and that in human beings, the soul was like a ghost that kind of inhered inside the machine.

And that became the basis for philosopher Gilbert Ryle’s comment that we’re sort of like a “ghost in a machine.” But that was not the way that ancient philosophers looked at human beings. They didn’t look at us as machines inhabited by ghosts. They looked at us as integrated living things.

Whether we know specifically what Descartes said, we’ve all inherited his way of looking at us as if we’re meat machines of some sort. And if you assume that you’re a meat machine, then of course it’s difficult to distinguish mind from machine. And you say, well, how can a machine give rise to a mind?

And the fact is that a machine can’t give rise to a mind because a machine is defined as something that doesn’t have a mind. It’s just a mechanical arrangement of parts. So this confusion—the ancients never had a mind-brain problem. That never bothered them at all. They understood us as having souls, and souls are an integration of our physical abilities and our spiritual abilities. They’re all integrated. So the ancients didn’t have this mind-brain problem. That’s a modern problem. It comes from Descartes.

JAN JEKIELEK: From a scientific perspective, can you see that distinction?

DR. MICHAEL EGNOR: Yes, you can. It is not widely acknowledged in neuroscience because neuroscience works through a materialist bias. And neuroscientists who sort of stand up and say we have souls are few and far between. It can threaten one’s career if one says things like that too much. But when you look carefully at the neuroscience, the best neuroscience over the past century, it clearly points to the existence of the soul and to the existence of aspects of our mind that don’t come from the brain.

Brain Versus Mind: Understanding the Distinction

JAN JEKIELEK: Separate the brain and the mind for me, from a neuroscientist perspective.

DR. MICHAEL EGNOR: The brain is an organ, just like the heart, the lungs, the kidney, things like that. It does organ things. The organ things it does is it makes action potentials, electrical impulses in nerves. It makes neurotransmitters, chemicals that affect our mood and so on.

What we call the mind nowadays is simply various powers of the soul. The soul is all the things in us that make us alive. It’s not a ghostly thing. It’s not like this translucent thing that you can look through. The soul is just what makes us living human beings—our heartbeat, our breathing, our metabolism, our thinking, our talking, all that stuff.

And our soul gives us various powers, various abilities to do things.