Spring Behrouz: The Dynamic Future of Neuroscience (Full Transcript)

Neuroscientist Dr. Spring Behrouz discusses The Dynamic Future of Neuroscience at TEDxJacksonville conference (Transcript)

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We start in the future. The year is 2034. Alex has just come home. It’s his birthday, he turns 61 years old today. He comes home and before he puts his keys into the door to open the door, he remembers something. He lets his arms dangle to his side for a moment. No shaking, no resting tremor. Moves his arms up and down. No rigidity, no signs of Parkinson’s disease. He remembers when his mom was diagnosed with Parkinson’s disease when she was just 50 years old, much younger than he is today. And he remembers her frustrations with simple tasks like putting the keys in the door or even dressing herself.

He also remembers the day that he found out that he, just like his mom, carries a genetic mutation that makes it more likely for him to get the disease. Now, he shakes it off, opens the door, and goes inside and a loud noise of “Surprise!” greets him as his friends and family cheer and celebrate his birthday. His wife hands him a glass of champagne and everyone raises a toast, “To Alex!” He smiles to himself. Another year gone, and no sign of Parkinson’s disease. The drugs are working. He secretly raises a toast to the warriors, the champions, who changed his fate.

Now, let’s rewind, 10 years. The year is 2024. The new Parkinson’s disease drug has just received FDA approval after showing great promise in clinical trials. Not just in masking the symptoms of the disease, like the previous drugs, but actually stopping the progressive degeneration. This drug is nothing short of a miracle taking less than ten years; usually, the time line of drug development is long, over 15 years, and even then, a very high failure rate. This time, it was much faster.

This time, there were tools that predicted interactions and successes and avoided a sea of failed studies and negative data. Alex is still asymptomatic, but brain scans show there’s already some degeneration in his brain. He starts treatment immediately to avoid further damage.

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Let’s keep rewinding. The year is 2014. I stand here in front of you, and I tell you about two progressive and debilitating brain diseases: Parkinson’s disease and Alzheimer’s disease. I tell you that this is what happens to your brain in Alzheimer’s disease. And I ask you: what would you do to keep your brain from this fate? How much would you pay to save your most precious memories, your cognition, your identity?

What about Parkinson’s disease? What would you pay to keep enough motor control, to dress yourself, feed yourself, even go to the bathroom by yourself? And I tell you that as life expectancy grows, we will be faced with a dramatically higher number of both of these diseases with no cure. But there is hope.

I tell you that we are warriors, conquerors fighting these inhumane diseases. I tell you of revolutionary advances in the field of neuroscience and that we are on the verge of powerful, new tools like neurostimulation. This tool uses video game technology to create a model of what happens inside an individual neuron or brain cell. It allows us to put together the pieces of the puzzle and make our brains healthier which I think is an idea worth spreading.

Alex is here tonight. He hears this talk and joins the warriors. He decides to live better, learn more, and use his skills set to contribute to research. While we’re here already, let’s keep rewinding. The year is 2004. Scientists have just discovered a mutation in a gene called LRRK2. This genetic mutation significantly increases a person’s likelihood of getting Parkinson’s disease. Meanwhile, Alex is with his mom at the hospital, watching as the neurologist performs motor tests and trying to come to grip with his mom’s Parkinson’s disease, helpless. Neither he nor his mom have any idea that they both carry this newly discovered genetic mutation.

2004 was also the first year that I attended the Society for Neuroscience Meeting. I had just started my research on Parkinson’s disease, and I had my first piece of data in hand. I was so excited because I actually found something that no one else knew before. Not like researching on Google. Actually finding something that no one knew. It was like nature had whispered a little secret to me that I could tell the world. It was addictive.

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And when I went to this meeting, I saw 25,000 other neuroscientists and trainees who were just as giddy and excited about the brain as I was, each of them unlocking the ‘hows’ of the brain and the nervous system. How this fantastic system allows us to think, to learn, remember, to feel emotions, even see, hear, and move our bodies. If you had gone there, you would have, no doubt, seen a lot of nerds. And we are quite proudly nerds.

But I knew, standing there, at that moment in time, that we are warriors, explorers, we boldly go where no one has gone before. We are people who develop and utilize new tools and techniques so that we can explore the unknown, rethink what we already know, and reshape the fate of future generations. Look at the people next to you. You are one of the six people directly adjacent to you who’ll get Alzheimer’s disease. And while it looks bleak today, there is a bright future waiting us. But we must be diligent and there’s no time to waste. Every single one of you has the skill set, a weapon that can be used in this fight.

If you are here, if you are interested in ideas worth spreading, if you are curious enough, motivated enough, and spending your free time listening to TED talks, I have news for you, you are already one of us, you are a warrior. So unsheathe your weapons and stand with us because every action that we take now, will transform the fate of future generations. For people like Alex, for people like you and me.

Now, before I tell you my second story, I want to ask you a question: raise your hand if you would want to know if you have one of these genetic mutations that increases your risk for Alzheimer’s or Parkinson’s diseases. Oh, that’s good! Keep in mind there’s no cure still. If you raised your hand, it’s actually quite inexpensive, only about a hundred dollars and very quick, to get tested for this genetic mutations. If you didn’t raise your hand, I guess that’s something that we each have to decide for ourselves, but I tend to think that knowledge is always good, that by knowing our genetic risk, we can change our environments and our lifestyle factors. We can contribute to organizations like the Michael J. Fox Foundation for Parkinson’s or Alzheimer’s association. You have the power then, to reshape your own future.

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Now, for my second story. This story is about one tiny little neuron inside the brain of someone with Alzheimer’s or Parkinson’s disease. You can’t see it, it’s embedded deep inside the brain and protected by a very thick skull. And contrary to what you may have seen in the movies, on TV, or even in this animation, we don’t have any tools to be able to see this type of resolution, individual neurons in the brain. Let alone the molecules inside of these neurons. We can do a couple of things: we can take one of these neurons, stick it in the petri dish and look at it under microscope on the laboratory. It’s very cool. We can even tag different types of molecules, and we can see them move and change. But we miss everything else, we only see what we tag.

Another thing we can do is we can take these neurons, and we can look at a whole bunch of different things. For example, we can look at the concentrations of molecules inside them, the way they move, where they are located, their interactions. But we can only see it for one point in time because once we take that neuron for analysis, it’s dead, we can’t use it anymore. This is a huge limitation because the brain doesn’t look like this. The neurons are not static, they’re incredibly dynamic, moving, changing every millisecond.

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