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Home » Mel Robbins Podcast: w/ Dr. Anna Lembke on How to Get Motivated (Transcript)

Mel Robbins Podcast: w/ Dr. Anna Lembke on How to Get Motivated (Transcript)

Editor’s Note: Mel Robbins sits down with Stanford University’s Dr. Anna Lembke, a world-renowned expert on dopamine and addiction, to explore why modern life has left so many of us feeling unmotivated and stuck in a cycle of compulsive overconsumption. The discussion dives deep into the “pleasure-pain balance,” explaining how our brains respond to instantaneous hits of dopamine from phones and ultra-processed food by driving us into a chronic deficit state that makes everyday tasks feel like “Mount Everest.” Dr. Lembke outlines her actionable protocol for resetting the brain’s reward system, including the transformative benefits of “dopamine fasting” and the counterintuitive power of leaning into intentional discomfort to build lasting willpower. This insightful conversation offers an essential roadmap for anyone looking to reclaim their focus and rediscover genuine joy in an increasingly distracted world. (Jan 22, 2026)

TRANSCRIPT:

MEL ROBBINS: Please help me welcome Dr. Anna Lembke to the Mel Robbins Podcast.

DR. ANNA LEMBKE: Thank you for inviting me. I’m absolutely delighted to be here.

MEL ROBBINS: Dr. Lembke, could you tell me if I take everything to heart that you’re about to teach me today, and I truly apply all this research about dopamine and motivation and happiness and pain and pleasure centers, and I apply it to my life, how could my life change?

DR. ANNA LEMBKE: If you’re like me, and you’re like many of my patients, you are probably unconsciously organizing your entire life around reward and little dopamine hits. From the moment we wake up in the morning, we reach for our phones, we scroll, we go get our coffee with our caffeine. We get in the car, we’re listening to our music. It’s not interesting, we’re flipping the stations.

Then we get to work, and all of a sudden we have to let go of those instantaneous pleasures. Now we’re bored, we’re frustrated, we’re restless, we’re anxious, we can’t concentrate. So then we’re interrupting ourselves and saying, “Oh, I better check my phone, or maybe I should look at that video.” And we’re doing that through the entirety of the day until we get to the end of the day where we go home.

We can’t wait till we get there to have a glass of wine, watch our shows, eat a cupcake, and then have difficulty falling asleep at night because we’re so wound up and restless. So what I’m saying to you is that I hope by the end of the conversation, you can get out of the vortex of compulsive overconsumption and get to a place where you’re not constantly seeking these rewards, but instead really showing up for your life.

MEL ROBBINS: Oh, my God. Dr. Lembke, this is why I’ve been so excited to talk to you, because you just explained every single one of us, and we’re in it. And so we don’t see how the constant distraction and reaching for all these things and everything you just described.

So what I got already so far is that a lot of your work centers around the fact that as a human being, we have this kind of natural system inside us that we will move, right, like a freight train towards what feels really good, but we reflexively move away from anything that might feel hard. Is that kind of what you’re talking about?

DR. ANNA LEMBKE: Yes. Very nicely summarized.

Understanding Dopamine: The Brain’s Reward Chemical

MEL ROBBINS: Okay. And your research in particular focuses on dopamine. So let’s just start at the basics. What exactly is dopamine, and why is it important?

DR. ANNA LEMBKE: Okay, so dopamine is a chemical that we make in our brain. It’s what’s called a neurotransmitter. Neurotransmitters are the molecules that bridge the gap between neurons. Neurons are these long, spindly cells that conduct electrical circuits. Our brains are fundamentally a bunch of wires. But those wires, the neurons don’t actually touch end to end. There’s a little space between them. So that space is called the synapse.

MEL ROBBINS: Okay.

DR. ANNA LEMBKE: And neurotransmitters bridge that gap between neurons to allow for fine-tuned control of those electrical circuits. Dopamine has many different functions, but one of its most important functions is in pleasure, reward, and motivation.

Now, it’s not the only neurotransmitter involved in that process, but it has become a kind of common currency for neuroscientists to measure the reinforcing potential of different substances and behaviors. Fundamentally, the more dopamine that is released in the brain’s reward pathway, and the faster that it’s released, the more likely is that substance to be reinforcing or something that our brain recognizes as important for survival. Something to approach, explore, and potentially exploit by doing it again and again.

MEL ROBBINS: So let me just give this back to you to see if I’m understanding this. Your brain releases these chemicals. Dopamine is one of them. And dopamine is related to motivation and pleasure.

DR. ANNA LEMBKE: Yes. A more fundamental way to talk about it is it’s related to reinforcement. So something that I do that’s often associated with pleasure, but not exclusively associated with pleasure, which then I want to do again and again because my brain recognizes it as potentially important for survival.

MEL ROBBINS: How important is dopamine in terms of the role that it plays when you are trying to either break and replace bad habits or create new positive habits? You see what I mean?

I can understand what you’re talking about, because the thing I immediately thought of is whenever I’ve heard anybody talk about something like heroin or oxycontin or something like that, that first time that somebody sadly uses it, there’s this boom, huge reward. And then experts are very clear that the reward or the spike that you’re getting declines with every use. But the poor person who is addicted is chasing that initial first spike and that feeling, even though it’s not coming.

DR. ANNA LEMBKE: Exactly.