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Microbiome: Gut Bugs and You by Warren Peters (Full Transcript)

Warren Peters

Dr. Warren Peters meets his patients every day with a broad smile and a passion to make complex things simple, so people can make those difficult healthy lifestyle changes which will enhance their well-being.

In this talk, Warren Peters takes you on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer’s disease, autism, and our everyday health and wellness.

Dr. Warren Peters – TEDx Talk TRANSCRIPT

When I was just a little boy, when I used the toilet, my mother taught me to wash my hands, and when I flushed and I looked at what was going down, I’d go, boy, you’d better wash your hands, you know?

And I had this little puppy, you know, this little dog, and when I saw what came out of his body, and if I stepped in it, I’d go, boy, I’d better wash my hands. And my mother taught me all about germs and how bad they were, and you should always wash your hands, and I believed her.

And then I grew up and I went to medical school, and we had the microscope. And we looked at these bacteria, and we heard these stories about how they caused these epidemics, and people dying all over the place, and then antibiotics came aboard.

And now we could actually stamp out these epidemics of these bad germs. And then, all of a sudden, I started hearing about the good bugs, and I go, “What’s that?”

And as we began to look at the actual genetics, this was the breakthrough that allowed us to actually understand our microbiome, particularly in our GI tract, because when I was just looking at them through a microscope, it was very limiting.

You could only see just certain kinds, but now that we could actually genetically look at this – this all started about 10 years ago, and many of you are familiar with this – when they started looking at the genetics of the human, what are the genes? How many genes? What are the genes that we have?

Through incredible research, it became apparent that we actually had, like, 26,000 genes. And I thought, wow, that’s really cool, and everybody was studying the genes and this was really wonderful, until they started studying the genes of a rice plant.

The rice plant had 46,000 genes. What’s that?! You know, I mean, we’re only 26 and they’re 46?! And so this was very humbling to say that the rice plant was more sophisticated than humans.

So then about five years ago everybody got busy, and they started to do the genome of the bacteria that resides inside of our body. Guess how many genes there are there: 100,000 genes.

And so we began to look at, what are these bugs? Who are these? What are these? So there’s, like, 100 trillion of them. When we think of cells of our body, our biome describes 90% of all the cells. We’re only 10%.

So we just heard how wonderful it is to look at the astronomy and be humbled. I would suggest we probably just need to look inside of us and really get humble because “the other” is way beyond this.

So these genes are incredible – there’s about 1,000 different varieties, and then when we look at the species and sort of like that, it’s incredible how diverse this whole environment, this whole biome is, and just resides in some just humble you and me.

Well, okay, let’s team up with our bugs. So we’re 26,000 and they’re 100,000. Wow, now we can trump the rice plant, so we better stay joined with them.

So we begin to do – what actually does this biome do for us? So we first think of fermentation – talk about a microbrewery, you know, right here in our right colon, right here, these bugs are actually fermenting because this does a lot of good things, and they produce about the equivalent of a can of beer every day. And, yeah, that’s true.

And so, of course, we handle it quite nicely and so on, we don’t get tipsy with that much. And so in this process of fermentation, some very important things are created; they’re called short-chain fatty acids. These short-chain fatty acids are critical to our immune system.

So if you breed a little mouse that has no biome, this little creature is very vulnerable to infections and so on. And so in many ways, this is quite dramatic, and we wonder, where does this biome come from? Because the little human, when he’s just inside the uterus, he doesn’t have a lot of bugs – this has been kind of coming in question here, like, right now – but so far, we’ve always thought of it being kind of sterile inside there.

But when this little child goes through the birth canal and is breastfed, that is where the microbiome starts. This is critical to the life of this child, and our C-section babies and our babies that don’t get breastfed, this is very difficult.

So now, in modern places and hospitals that understand this, if the little child has to be born by C-section, a vaginal swab is actually taken and placed in the child’s face and mouth so that they can actually become a mirobiome-positive creature, otherwise the immune system would not develop.

So this is very, very vital, so that’s kind of the positive side of the fermentation.


But there’s a negative side to this, and this is where – remember all these cells, these thousands of different kinds of bacteria – like most of life, it’s about a balance, and when they are not balanced, we call it a dysbiosis. When that begins to happen, we find that it starts causing diseases.

You know the word “irritable bowel syndrome”? Some of you may actually have it – you know, diarrhea, constipation, abdominal cramps, all these kind of things.

You know about colitis, you’ve heard of people that have colitis. These kinds of things are when there is a dysbiosis, there’s an imbalance between the good bugs and the bad bugs.

Also, we’re beginning to understand that a lot of the – what is called – autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, these kind of things may indeed be associated with an imbalance in our microbiome.

So another things that our bugs do is they harvest calories. Now, if you’re starving to death, and you’re having to eat a lot of grasses and grains, and things that have a lot of fiber, your body can only absorb a certain number of calories, and we can’t absorb, normally, any calories from fiber.

Fiber just goes down to the biome, and the biome actually will harvest from the fiber, will actually harvest an extra 10% to 15% of the calories from that food we’ve eaten. This is how humanity has survived very, very severe circumstances.

But just as there’s a positive, there’s also a negative. And we find when we look at this whole obese area, people who are overweight – Anybody have any deficit of calories? Lunch looked pretty good, didn’t it? So we’re not living in a cave anymore and we’re not starving.


So this good thing can then become a bad thing, particularly if we tend towards these particular kind of bugs, they’re called Firmicutes – it’s a big family group – and they harvest extra calories. So when we actually look at the biome of people who are overweight or people who have diabetes, they tend to have a lot more of this Firmicutes family.

Are you following me? Do you see where this is starting to lead? What if we begin to change the biome to a more balanced biome for people that were overweight? Ha! You know how this is going to go, don’t you? And the studies are already being done in mice, but you know, there’s a lot to this.

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